The Relationship Between Maternal Age and the Incidence of Abortion in First-Trimester Pregnancies at Bolsel Regional General Hospital
Keywords:
Anemia, First Trimester of Pregnancy, High-Risk Reproductive Age, Maternal Age, MiscarriageAbstract
Miscarriage is one of the complications of first-trimester pregnancy that remains a significant cause of maternal morbidity and is influenced by various factors, one of which is maternal age. Although reproductive age is often associated with an increased risk of miscarriage, research findings across various regions still show inconsistencies. This study aims to analyze the relationship between maternal age and the incidence of abortion during the first trimester of pregnancy at the South Bolaang Mongondow Regional General Hospital (BolSel). The study employed a quantitative analytical design with a cross-sectional approach. The study sample consisted of 30 pregnant women in their first trimester, selected using total sampling. Data were obtained through a review of medical records and observation forms, then analyzed univariately and bivariately using the Contingency Coefficient test with a 95% confidence level. The results showed that the majority of respondents were aged 20–35 years (73.3%) and experienced anemia (93.3%), hypotension (53.3%), and spontaneous abortion (70.0%). Bivariate analysis results showed no significant association between maternal age and the incidence of abortion in the first trimester of pregnancy (p=0.392; r=0.244). These findings indicate that maternal age is not a major factor associated with the incidence of abortion in the study population, whereas other clinical factors such as anemia, hypotension, and a history of abortion are believed to play a greater role. The results of this study underscore the importance of comprehensive antenatal screening that focuses not only on maternal age but also on maternal clinical conditions to support the prevention of miscarriage and improve the quality of maternal health care.
References
Amalia, R., & Rahmawati, D. (2022). Pathophysiology of placental hypoxia due to iron-deficiency anemia and its impact on early pregnancy termination. Journal of Maternal Nursing, 11(2), 134–142.
Bearak, J., Popinchalk, A., Ganatra, B., Moller, A. B., Tunçalp, Ö., Beavin, C., & et al. (2020). Unintended pregnancy and abortion by income, region, and the legal status of abortion: Estimates from a comprehensive model for 1990–2019. The Lancet Global Health, 8(9), e1152–e1161. https://doi.org/10.1016/S2214-109X(20)30315-6
Brown, L. A., & Green, S. M. (2024). Sample size constraints and statistical power limitations in observational maternal-fetal research. Journal of Biometrics in Health, 39(1), 56–67.
Dewi, R. C., Saputra, A., & Nugroho, S. (2023). Multivariate analysis of risk factors for spontaneous abortion at a regional referral hospital. Indonesian Journal of Midwifery, 14(3), 189–198.
Fitriani, N., & Lestari, P. (2025). The effect of maternal hypotension and anemia on the incidence of fetal distress and first-trimester abortion. Journal of Reproduction and Neonatology, 7(1), 23–31.
Keswara, N. W., & Laksono, B. B. (2024). Analysis of knowledge, attitude, and use of the KIA book regarding emergency signs and symptoms in pregnancy. Babali Nursing Research, 5(2), 288–296. https://doi.org/10.37363/bnr.2024.52366
Kurniawan, B., & Saputra, M. (2021). The relationship between hemoglobin levels and the integrity of chorionic villi in abortion tissue samples at the anatomical pathology laboratory. Indonesian Medical Journal, 71(4), 215–222.
Magnus, M. C., Wilcox, A. J., Morken, N. H., Weinberg, C. R., & Håberg, S. E. (2019). Role of maternal age and pregnancy history in the risk of miscarriage: A prospective register-based study. BMJ, 364, l869. https://doi.org/10.1136/bmj.l869
Martinez, J. E., Nelson, K., & Santos, M. E. (2023). Recurrent pregnancy loss: Evaluation of immunologic and historical risk factors. International Journal of Gynecology & Obstetrics, 162(2), 401–411.
Ministry of Health of the Republic of Indonesia. (2024). Indonesia health profile 2023. Ministry of Health of the Republic of Indonesia.
Pratiwi, F., & Wulandari, S. (2024). Hemodynamic profiles of pregnant women in the first trimester and their association with gestational stability. Journal of Nutrition and Health, 16(2), 102–111.
Quenby, S., Gallos, I. D., Dhillon-Smith, R. K., Podesek, M., Stephenson, M. D., Fisher, J., & et al. (2021). Miscarriage matters: The epidemiological, physical, psychological, and economic costs of early pregnancy loss. The Lancet, 397(10285), 1658–1667. https://doi.org/10.1016/S0140-6736(21)00682-6
Rai, R., & Regan, L. (2021). Recurrent miscarriage. The Lancet, 397(10285), 1675–1685. https://doi.org/10.1016/S0140-6736(21)00681-4
Sari, N. P., & Putri, R. (2022). Clinical and laboratory characteristics of patients with threatened abortion at secondary health facilities. Journal of Public Health, 17(3), 145–154.
Smith, N. L., & Jones, T. R. (2025). Advanced maternal age and chromosomal aneuploidy versus environmental risk factors in early pregnancy loss. Journal of Perinatology, 45(1), 89–99.
Steegers, E. A. P., von Dadelszen, P., Duvekot, J. J., & Pijnenborg, R. (2021). Preeclampsia and maternal health: Broader implications for pregnancy outcomes. The Lancet.
UNICEF. (2023). The state of the world’s children 2023. UNICEF.
Utami, T., Santoso, B., & Siregar, M. (2023). Dominant factors in spontaneous abortion in eastern Indonesia: A cross-sectional study. Journal of Health Epidemiology, 12(1), 45–55.
World Health Organization. (2023a). Abortion care guideline. World Health Organization.
World Health Organization. (2023b). Maternal and perinatal health. World Health Organization.
World Health Organization. (2023c). WHO recommendations on antenatal care for a positive pregnancy experience. World Health Organization.



